Bacterial diet affects vulval organogenesis in Caenorhabditis elegans Mediator kinase module mutants
نویسندگان
چکیده
منابع مشابه
Computational insights into Caenorhabditis elegans vulval development.
Studies of Caenorhabditis elegans vulval development provide a paradigm for pattern formation during animal development. The fates of the six vulval precursor cells are specified by the combined action of an inductive signal that activates the EGF receptor mitogen-activated PK signaling pathway (specifying a primary fate) and a lateral signal mediated by LIN-12/Notch (specifying a secondary fat...
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MOTIVATION Caenorhabditis elegans vulval development is a paradigmatic example of animal organogenesis with extensive experimental data. During vulval induction, each of the six multipotent vulval precursor cells (VPCs) commits to one of three fates (primary, secondary, tertiary). The precise primary-secondary-tertiary formation of VPC fates is controlled by a network of intercellular signaling...
متن کاملTranscriptional network underlying Caenorhabditis elegans vulval development.
The vulval development of Caenorhabditis elegans provides an opportunity to investigate genetic networks that control gene expression during organogenesis. During the fourth larval stage (L4), seven vulval cell types are produced, each of which executes a distinct gene expression program. We analyze how the expression of cell-type-specific genes is regulated. Ras and Wnt signaling pathways play...
متن کاملNegative Regulators of Caenorhabditis elegans Vulval Development
During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 muta...
متن کاملOrganogenesis of the Caenorhabditis elegans intestine.
The intestine of Caenorhabditis elegans is an epithelial tube consisting of only 20 cells and is derived clonally from a single embryonic blastomere called E. We describe the cellular events that shape the intestine. These events include cytoplasmic polarization of cells in the intestinal primordium, the intercalation of specific sets of cells, the generation of an extracellular cavity within t...
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ژورنال
عنوان ژورنال: Matters
سال: 2016
ISSN: 2297-8240
DOI: 10.19185/matters.201605000012